Methyl CpG binding protein 2 (MeCP2) was initially isolated as an exclusive reader of DNA methylated at CpG. This recognition site, was subsequently extended to other DNA methylated residues and it has been the persisting dogma that binding to methylated DNA constitutes its physiologically relevant role. As we review here, two very recent papers fundamentally change our understanding of the interactions of this protein with chromatin, as well as its functional attributes. In the first one, the protein has been shown (...) to bind to tri‐methylated histone H3 (H3K27me3), providing a hint for what might turn out to be the first described chromodomain‐containing protein reader in the animal kingdom, and unequivocally demonstrates the ability of MeCP2 to bind to nonmethylated CpG regions of the genome. The second paper reports how the protein dynamically participates in the formation of constitutive heterochromatin condensates. Histone H3K27me3 is a critical component of this form of chromatin. (shrink)

Hugh H. Benson explores Plato's answer to Clitophon's challenge, the question of how one can acquire the knowledge Socrates argues is essential to human flourishing-knowledge we all seem to lack. Plato suggests two methods by which this knowledge may be gained: the first is learning from those who already have the knowledge one seeks, and the second is discovering the knowledge one seeks on one's own. The book begins with a brief look at some of the Socratic dialogues where (...) Plato appears to recommend the former approach while simultaneously indicating various difficulties in pursuing it. The remainder of the book focuses on Plato's recommendation in some of his most important and central dialogues-the Meno, Phaedo, and Republic-for carrying out the second approach: de novo inquiry. The book turns first to the famous paradox concerning the possibility of such an inquiry and explores Plato's apparent solution. Having defended the possibility of de novo inquiry as a response to Clitophon's challenge, Plato explains the method or procedure by which such inquiry is to be carried out. The book defends the controversial thesis that the method of hypothesis, as described and practiced in the Meno, Phaedo, and Republic, is, when practiced correctly, Plato's recommended method of acquiring on one's own the essential knowledge we lack. The method of hypothesis when practiced correctly is, then, Platonic dialectic, and this is Plato's response to Clitophon's challenge. (shrink)

While the early Platonic dialogues have often been explored and appreciated for their ethical content, this is the first book devoted solely to the epistemology of Plato's early dialogues. Author Hugh H. Benson argues that the characteristic features of these dialogues--Socrates' method of questions and answers, his fascination with definition, his professions of ignorance, and his thesis that virtue is knowledge--are decidedly epistemological. In this thoughtful study, Benson uncovers the model of knowledge that underlies these distinctively Socratic views. (...) What emerges is unfamiliar, yet closer to a contemporary conception of scientific understanding than ordinary knowledge. (shrink)

While the early Platonic dialogues have often been explored and appreciated for their ethical content, this is the first book devoted solely to the epistemology of Plato's early dialogues. Author Hugh H. Benson argues that the characteristic features of these dialogues- -Socrates' method of questions and answers, his fascination with definition, his professions of ignorance, and his thesis that virtue is knowledge- -are decidedly epistemological. In this thoughtful study, Benson uncovers the model of knowledge that underlies these distinctively (...) Socratic views. What emerges is unfamiliar, yet closer to a contemporary conception of scientific understanding than ordinary knowledge. (shrink)

The last two decades have witnessed a virtual explosion of research in Socratic philosophy. This volume collects essays that represent the range and diversity of that vast literature, including historical and philosophical essays devoted to a single Platonic dialogue, as well as essays devoted to the Socratic method, Socratic epistemology, and Socratic ethics. With lists of suggested further readings, an extensive bibliography on recent Socratic research, and an index locorum, this unique and much-needed anthology makes the study of Socratic philosophy (...) accessible to both scholars and non-specialists. (shrink)

This broad-ranging _Companion_ comprises original contributions from leading Platonic scholars and reflects the different ways in which they are dealing with Plato’s legacy. Covers an exceptionally broad range of subjects from diverse perspectives Contributions are devoted to topics, ranging from perception and knowledge to politics and cosmology Allows readers to see how a position advocated in one of Plato’s dialogues compares with positions advocated in others Permits readers to engage the debate concerning Plato’s philosophical development on particular topics Also includes (...) overviews of Plato’s life, works and philosophical method. (shrink)

This chapter contains sections titled: Preliminaries The Elenchos The Method of Hypothesis The Method of Dialectic Conclusion.

This chapter contains sections titled: Dialectic with a Small “d” Plato on Dialectic in the Meno, Phaedo, and Republic Plato's Practice of Dialectic in the Meno, Phaedo, and Republic The Second‐Best Method Note.

Miller undermines traditional ideas and beliefs about language, literature, truth, meaning, consciousness, and interpretation. In effect, he assumes the role of unrelenting destroyer—or nihilistic magician—who dances demonically upon the broken and scattered fragments of the Western tradition. Everything touched soon appears torn. Nothing is ever finally darned over, or choreographed for coherence, or foregrounded as magical illusion. Miller, the relentless rift-maker, refuses any apparent repair and rampages onward, dancing, spell-casting, destroying all. As though he were a wizard, he appears in (...) the guise of a bull-deconstructer loose in the china shop of Western tradition. Vincent B. Leitch, associate professor of English at Mercer University, is the editor of Robert Southwell's Marie Magdalens Funeral Teares and The Poetry of Estonia: Essays in Comparative Analysis. Sections of the present essay will appear in his The Poetics of Deconstruction, which offers a critical history and anatomy of deconstructive criticism. (shrink)

Although "the Socratic method" is commonly understood as a style of pedagogy involving cross-questioning between teacher and student, there has long been debate among scholars of ancient philosophy about how this method as attributed to Socrates should be defined or, indeed, whether Socrates can be said to have used any single, uniform method at all distinctive to his way of philosophizing. This volume brings together essays by classicists and philosophers examining this controversy anew. The point of departure for many of (...) those engaged in the debate has been the identification of Socratic method with "the elenchus" as a technique of logical argumentation aimed at refuting an interlocutor, which Gregory Vlastos highlighted in an influential article in 1983. The essays in this volume look again at many of the issues to which Vlastos drew attention but also seek to broaden the discussion well beyond the limits of his formulation. Some contributors question the suitability of the elenchus as a general description of how Socrates engages his interlocutors; others trace the historical origins of the kinds of argumentation Socrates employs; others explore methods in addition to the elenchus that Socrates uses; several propose new ways of thinking about Socratic practices. Eight essays focus on specific dialogues, each examining why Plato has Socrates use the particular methods he does in the context defined by the dialogue. Overall, representing a wide range of approaches in Platonic scholarship, the volume aims to enliven and reorient the debate over Socratic method so as to set a new agenda for future research. Contributors are Hayden W. Ausland, Hugh H. Benson, Thomas C. Brickhouse, Michelle Carpenter, John M. Carvalho, Lloyd P. Gerson, Francisco J. Gonzalez, James H. Lesher, Mark McPherran, Ronald M. Polansky, Gerald A. Press, François Renaud, and W. Thomas Schmid, Nicholas D. Smith, P. Christopher Smith, Harold Tarrant, Joanne B. Waugh, and Charles M. Young. (shrink)